2. Academic Validation
  3. Effects of prenatal bisphenol S and bisphenol F exposure on behavior of offspring mice

Effects of prenatal bisphenol S and bisphenol F exposure on behavior of offspring mice

  • Anim Cells Syst (Seoul). 2023 Oct 11;27(1):260-271. doi: 10.1080/19768354.2023.2264905.
Ha Jung Moon 1,  Hyun Seung Shin 1,  Seung Hyun Lee 1,  Eui-Ju Hong 2,  Changhwan Ahn 3,  Yeong-Min Yoo 4,  Eui-Bae Jeung 5,  Geun-Shik Lee 6,  Beum-Soo An 7,  Eui-Man Jung 1
Affiliations

Affiliations

  • 1 Department of Molecular Biology, College of Natural Sciences, Pusan National University, Busan, Republic of Korea.
  • 2 Department of Veterinary Medicine, Chungnam National University, Daejeon, Republic of Korea.
  • 3 Department of Veterinary Medicine, Jeju National University, Jeju, Republic of Korea.
  • 4 East Coast Life Sciences Institute, College of Life Science, Gangneung-Wonju National University, Gangneung, Republic of Korea.
  • 5 Laboratory of Veterinary Biochemistry and Molecular Biology, Veterinary Medical Center and College of Veterinary Medicine, Chungbuk National University, Cheongju, Republic of Korea.
  • 6 Department of Veterinary Medicine, Kangwon National University, Chuncheon, Republic of Korea.
  • 7 Department of Biomaterials Science (BK21 Four Program), College of Natural Resources & Life Science, Pusan National University, Miryang, Republic of Korea.
PMID: 37842186 DOI: 10.1080/19768354.2023.2264905
Abstract

Bisphenol A (BPA) is a representative endocrine-disrupting chemical that exhibits hormonal disturbance reactions. Various alternatives, such as Bisphenol S (BPS) and Bisphenol F (BPF), are being developed. BPS and BPF (which are representative alternatives to BPA) are used in consumer products such as polycarbonate plastics and epoxy resins. They have structures similar to those of BPA and have also been proven to be exogenous endocrine disruptors. However, although there are many studies on BPA, there are few studies on the neurodevelopmental effects of BPS and BPF. Therefore, in this study, we analyzed neurobehavioral changes in offspring mice exposed to BPS and BPF during brain development by administering BPS and BPF to pregnant mice. We found that prenatal exposure to BPS and BPF did not affect anxiety-and depression-like behaviors, locomotion, sociability, memory, or cognition functions in offspring mice. However, exposure to BPS and BPF decreased the preference for social novelty in the offspring mice. Taken together, these findings suggest that perinatal exposure to BPS and BPF affects changes in social behaviors, but not Other behavioral changes such as emotion, memory, or cognition in the offspring mice.

Keywords

BPF; BPS; Endocrine disrupting chemicals; brain development.

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