2. Academic Validation
  3. SQ 30,957, a new antibiotic produced by Penicillium funiculosum. Taxonomy, fermentation, isolation, structure determination, synthesis and antibacterial activity

SQ 30,957, a new antibiotic produced by Penicillium funiculosum. Taxonomy, fermentation, isolation, structure determination, synthesis and antibacterial activity

  • J Antibiot (Tokyo). 1986 Aug;39(8):1054-8. doi: 10.7164/antibiotics.39.1054.
P D Singh,  J H Johnson,  C A Aklonis,  J O'Sullivan
PMID: 3759656 DOI: 10.7164/antibiotics.39.1054
Abstract

A new Antibiotic, SQ 30,957, 4-diazo-3-methoxy-2,5-cyclohexadien-1-one, has been isolated from fermentation broths of Penicillium funiculosum. The structure (1) was deduced from its spectroscopic properties and its degradation reaction. SQ 30,957 has excellent activity against anaerobic bacteria such as Clostridium and Bacteroides and has moderate activity against aerobic bacteria. The compound has an LD50 of less than 17 mg/kg in mice by intraperitoneal administration.

Figures
Products