2. Academic Validation
  3. Structures of new antibiotics napyradiomycins

Structures of new antibiotics napyradiomycins

  • J Antibiot (Tokyo). 1986 Apr;39(4):494-501. doi: 10.7164/antibiotics.39.494.
K Shiomi,  H Nakamura,  H Iinuma,  H Naganawa,  K Isshiki,  T Takeuchi,  H Umezawa,  Y Iitaka
PMID: 3710910 DOI: 10.7164/antibiotics.39.494
Abstract

Structures of novel Antibiotics, napyradiomycins A, B1, B2, B3, C1 and C2 were determined. By X-ray crystallography, napyradiomycin B2 was determined to be (3R,10aR)-3-chloro-10a-[[(1R,3S)-3-chloro-2, 2-dimethyl-6-methylenecyclohexyl]methyl]-3,10a-dihydro-6,8-dihydro xy-2, 2-dimethyl-2H-naphtho[2,3-b]pyran-5,10-dione. The structures of Other napyradiomycins were elucidated by NMR studies. Napyradiomycins C1 and C2 have unique structures which contain 14-membered ring cyclized by carbon-carbon bond.

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