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  3. A review on tragacanth gum: A promising natural polysaccharide in drug delivery and cell therapy

A review on tragacanth gum: A promising natural polysaccharide in drug delivery and cell therapy

  • Int J Biol Macromol. 2023 Jun 30:241:124343. doi: 10.1016/j.ijbiomac.2023.124343.
Zahra Nazemi 1,  Maryam Sahraro 2,  Mahsa Janmohammadi 1,  Mohammad Sadegh Nourbakhsh 3,  Houman Savoji 4
Affiliations

Affiliations

  • 1 Faculty of New Sciences and Technologies, Semnan University, P.O. Box 19111-35131, Semnan, Iran.
  • 2 Department of Polyurethane and Advanced Materials, Iran Polymer & Petrochemical Institute, P.O. Box 14965-115, Tehran, Iran. Electronic address: m.sahraroo.chemist@gmail.co.
  • 3 Faculty of New Sciences and Technologies, Semnan University, P.O. Box 19111-35131, Semnan, Iran; Faculty of Materials and Metallurgical Engineering, Semnan University, P.O. Box 19111-35131, Semnan, Iran. Electronic address: s_nourbakhsh@semnan.ac.ir.
  • 4 Institute of Biomedical Engineering, Department of Pharmacology and Physiology, Faculty of Medicine, University of Montreal, Montreal, QC H3T 1J4, Canada; Research Center, Centre Hospitalier Universitaire Sainte-Justine, Montreal, QC H3T 1C5, Canada; Montreal TransMedTech Institute, Montreal, QC H3T 1J4, Canada. Electronic address: houman.savoji@umontreal.ca.
PMID: 37054856 DOI: 10.1016/j.ijbiomac.2023.124343
Abstract

Tragacanth is an abundant natural gum extracted from some Plants and is dried for use in various applications from industry to biomedicines. It is a cost-effective and easily accessible polysaccharide with desirable biocompatibility and biodegradability, drawing much attention for use in new biomedical applications such as wound healing and tissue engineering. Moreover, this anionic polysaccharide with a highly branched structure has been used as an emulsifier and thickening agent in pharmaceutical applications. In addition, this gum has been introduced as an appealing biomaterial for producing engineering tools in drug delivery. Furthermore, the biological properties of tragacanth gum have made it a favorable biomaterial in cell therapies, and tissue engineering. This review aims to discuss the recent studies on this natural gum as a potential carrier for different drugs and cells.

Keywords

Cell therapy; Drug delivery; Hydrogel; Tragacanth gum.

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