2. Academic Validation
  3. Cytotoxic derivatives of dichloroacetic acid and some metal complexes

Cytotoxic derivatives of dichloroacetic acid and some metal complexes

  • Arch Pharm (Weinheim). 2022 Nov;355(11):e2200236. doi: 10.1002/ardp.202200236.
Mohammad Hossain 1,  Shayne Roth 1,  Jonathan R Dimmock 2,  Umashankar Das 2
Affiliations

Affiliations

  • 1 School of Sciences, Indiana University Kokomo, Kokomo, Indiana, USA.
  • 2 Drug Discovery and Development Research Cluster, University of Saskatchewan, Saskatoon, Saskatchewan, Canada.
PMID: 35986437 DOI: 10.1002/ardp.202200236
Abstract

This study outlines a number of studies of dichloroacetic acid (DCA) and some of its derivatives. Although DCA has low cytotoxic potencies, various structural modifications are described which result in potent cytotoxins. In particular, hybrid molecules created from DCA and Other bioactive molecules whose modes of action differ from DCA are particularly promising as candidate Anticancer agents. Considerable emphasis in this review is placed on various series of compounds that incorporate both platinum and DCA into their structures. In addition, the importance of the formulation of some of the bioactive compounds described herein is revealed.

Keywords

anticancer; dichloroacetate; dichloroacetic acid; metal complexes; mitochondria.

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