2. Academic Validation
  3. Natural product diversity from the endophytic fungi of the genus Aspergillus

Natural product diversity from the endophytic fungi of the genus Aspergillus

  • RSC Adv. 2020 Jun 9;10(37):22058-22079. doi: 10.1039/d0ra04290k.
Seham S El-Hawary 1,  Abeer S Moawad 2,  Hebatallah S Bahr 3,  Usama Ramadan Abdelmohsen 4 5,  Rabab Mohammed 2
Affiliations

Affiliations

  • 1 Department of Pharmacognosy, Faculty of Pharmacy, Cairo University 11936 Cairo Egypt.
  • 2 Department of Pharmacognosy, Faculty of Pharmacy, Beni-Suef University 62514 Beni-Suef Egypt rababmohammed@pharm.bsu.edu.eg.
  • 3 Department of Pharmacognosy, Faculty of Pharmacy, Nahda University 62513 Beni-Suef Egypt.
  • 4 Department of Pharmacognosy, Faculty of Pharmacy, Minia University 61519 Minia Egypt usama.ramadan@mu.edu.eg.
  • 5 Department of Pharmacognosy, Faculty of Pharmacy, Deraya University, Universities Zone P. O. Box 61111 New Minia City Minia Egypt.
PMID: 35516645 DOI: 10.1039/d0ra04290k
Abstract

The endophytic fungus Aspergillus is considered as an enormous source of chemical leads with promising biological activities. Different Aspergillus species have proved their ability to produce plenty of secondary metabolites including butenolides, Alkaloids, Terpenoids, cytochalasins, phenalenones, ρ-terphenyls, Xanthones, sterols, diphenyl ether and anthraquinone derivatives with diverse biological activities, such as anti-cancer, Antifungal, anti-bacterial, anti-viral, anti-inflammatory, antitrypanosomal and antileishmanial activities. From January 2015 until December 2019, three hundred and sixty-one secondary metabolites were reported from different endophytic Aspergillus species. This review discusses the isolated secondary metabolites from different endophytic Aspergillus species reported from January 2015 to December 2019 along with their reported biological activities and structural aspects whenever applicable.

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