2. Academic Validation
  3. Topology-Dependent Interaction of Cyclic Poly(ethylene glycol) Complexed with Gold Nanoparticles against Bovine Serum Albumin for a Colorimetric Change

Topology-Dependent Interaction of Cyclic Poly(ethylene glycol) Complexed with Gold Nanoparticles against Bovine Serum Albumin for a Colorimetric Change

  • Langmuir. 2022 May 3;38(17):5286-5295. doi: 10.1021/acs.langmuir.1c03027.
Onyinyechukwu Justina Oziri 1,  Masatoshi Maeki 2,  Manabu Tokeshi 2,  Takuya Isono 2,  Kenji Tajima 2,  Toshifumi Satoh 2,  Shin-Ichiro Sato 2,  Takuya Yamamoto 2
Affiliations

Affiliations

  • 1 Graduate School of Chemical Sciences and Engineering, Hokkaido University, Sapporo, Hokkaido 060-8628, Japan.
  • 2 Division of Applied Chemistry, Faculty of Engineering, Hokkaido University, Sapporo, Hokkaido 060-8628, Japan.
PMID: 34878285 DOI: 10.1021/acs.langmuir.1c03027
Abstract

Unique physical and chemical properties arising from a polymer topology recently draw significant attention. In this study, cyclic poly(ethylene glycol) (c-PEG) was found to significantly interact with bovine serum albumin (BSA), suggested by nuclear magnetic resonance, dynamic light scattering, and fluorescence spectroscopy. On the Other hand, linear HO-PEG-OH and MeO-PEG-OMe showed no affinity. Furthermore, a complex of gold nanoparticles and c-PEG (AuNPs/c-PEG) attracted BSA to form aggregates, and the red color of the AuNPs dispersion evidently disappeared, whereas ones with linear PEG or without PEG did not demonstrate such a phenomenon. The interactions among BSA, AuNPs, and PEG were investigated by changing the incubation time and concentration of the components by using UV-Vis and fluorescence spectroscopy.

Figures
Products