2. Academic Validation
  3. Biosynthesis of napyradiomycins

Biosynthesis of napyradiomycins

  • J Antibiot (Tokyo). 1987 Dec;40(12):1740-5. doi: 10.7164/antibiotics.40.1740.
K Shiomi 1,  H Iinuma,  H Naganawa,  K Isshiki,  T Takeuchi,  H Umezawa
Affiliations

Affiliation

  • 1 Institute of Microbial Chemistry, Tokyo, Japan.
PMID: 3429338 DOI: 10.7164/antibiotics.40.1740
Abstract

Biosynthetic studies on napyradiomycins were carried out based on the incorporation of [2-13C]acetate and [1,2-13C]acetate. The alignment of acetate units suggested that the B and C rings of napyradiomycins are derived from a pentaketide, while ring A and the side chain may be synthesized from mevalonate.

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