2. Academic Validation
  3. Guaiazulene Triggers ROS-Induced Apoptosis and Protective Autophagy in Non-small Cell Lung Cancer

Guaiazulene Triggers ROS-Induced Apoptosis and Protective Autophagy in Non-small Cell Lung Cancer

  • Front Pharmacol. 2021 Apr 15:12:621181. doi: 10.3389/fphar.2021.621181.
Qin Ye 1,  Li Zhou 2,  Ping Jin 2,  Lei Li 3,  Shuwen Zheng 1,  Zhao Huang 2,  Jiayang Liu 2,  Siyuan Qin 2,  Hao Liu 1,  Bingwen Zou 4,  Ke Xie 1
Affiliations

Affiliations

  • 1 Department of Oncology, Sichuan Academy of Medical Sciences and Sichuan Provincial People's Hospital, School of Medicine, University of Electronic Science and Technology of China, Chengdu, China.
  • 2 State Key Laboratory of Biotherapy and Cancer Center, West China Hospital, West China School of Basic Sciences and Forensic Medicine, Collaborative Innovation Center for Biotherapy, Sichuan University, Chengdu, China.
  • 3 School of Basic Medical Sciences, Chengdu University of Traditional Chinese Medicine, Chengdu, China.
  • 4 Department of Thoracic Oncology and Department of Radiation Oncology, Cancer center, West China Hospital, Sichuan University, Chengdu, China.
PMID: 33935713 DOI: 10.3389/fphar.2021.621181
Abstract

Non-small cell lung Cancer (NSCLC) is one of the most frequent cancers worldwide, yet effective treatment remains a clinical challenge. Guaiazulene (GYZ), a cosmetic color additive, has previously been characterized as a potential antitumor agent due to observed Anticancer effects. However, the efficacy of GYZ in the treatment of NSCLC and the involved molecular mechanisms remain largely unknown. Here, we indicated a role for GYZ in the suppression of NSCLC both in vitro and in vivo via triggering Reactive Oxygen Species (ROS)-induced Apoptosis. Concomitantly, GYZ induced complete autophagic flux in NSCLC cells via inhibiting the Akt/mTOR signaling pathway, which displayed cytoprotective effect against GYZ-induced growth suppression. Accompanied with Autophagy inhibition obviously enhanced the effects of GYZ. Notably, GYZ acts synergistically with paclitaxel in the suppression of NSCLC in vitro. Together, our results for the first time reported that GYZ suppressed the proliferation of NSCLC and suggested a potential strategy for inhibiting NSCLC growth by combinational use of GYZ and Autophagy inhibitors.

Keywords

AKT/mTOR; apoptosis; autophagy; guaiazulene; non-small cell lung cancer.

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