Longipetalol A: A Highly Modified Triterpenoid from Dichapetalum longipetalum

J Nat Prod. 2021 May 28;84(5):1556-1562. doi: 10.1021/acs.jnatprod.1c00068.

Dong-Li Zhang ¹, Min Li ¹, Gui-Fang Han ¹, Shao-Yong Li ¹, De-Jun Jin ², Sheng-An Tang ¹

Affiliations

1 Tianjin Key Laboratory on Technologies Enabling Development of Clinical Therapeutics and Diagnostics, School of Pharmacy, Tianjin Medical University, Tianjin 300070, People's Republic of China.
2 School of Pharmacy, Hainan Medical University, Haikou, Hainan 571199, People's Republic of China.

PMID: 33914536 DOI: 10.1021/acs.jnatprod.1c00068

Abstract

Longipetalol A (1) is an unprecedented highly modified triterpenoid with a unique 1,2-seco-3-(2-oxo-phenylethyl)-17α-13,30-cyclodammarane skeleton, featuring an acetal-lactone fragment. It was isolated from Dichapetalum longipetalum along with two additional derivatives, namely, longipetalols B (2) and C (3). Their structures were elucidated using spectroscopic analyses combined with single-crystal X-ray diffraction. Compounds 1, 2, and 3 exhibited inhibitory effects on nitric oxide production in lipopolysaccharide-induced RAW264.7 macrophages.

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