2. Academic Validation
  3. Bifenazate exposure induces cardiotoxicity in zebrafish embryos

Bifenazate exposure induces cardiotoxicity in zebrafish embryos

  • Environ Pollut. 2021 Apr 1:274:116539. doi: 10.1016/j.envpol.2021.116539.
Jinze Ma 1,  Yong Huang 2,  Yuyang Peng 1,  Zhaopeng Xu 1,  Ziqin Wang 1,  Xiaobei Chen 1,  Shuling Xie 1,  Ping Jiang 1,  Keyuan Zhong 1,  Huiqiang Lu 3
Affiliations

Affiliations

  • 1 Ganzhou Key Laboratory for Drug Screening and Discovery, School of Geography and Environmental Engineering, Gannan Normal University, Ganzhou, 341000, Jiangxi, China.
  • 2 Ganzhou Key Laboratory for Drug Screening and Discovery, School of Geography and Environmental Engineering, Gannan Normal University, Ganzhou, 341000, Jiangxi, China; College of Chemistry and Chemical Engineering, Gannan Normal University, Ganzhou, 341000 Jiangxi, China.
  • 3 Ganzhou Key Laboratory for Drug Screening and Discovery, School of Geography and Environmental Engineering, Gannan Normal University, Ganzhou, 341000, Jiangxi, China; College of Chemistry and Chemical Engineering, Gannan Normal University, Ganzhou, 341000 Jiangxi, China; Jiangxi Engineering Laboratory of Zebrafish Modeling and Drug Screening for Human Diseases, Jiangxi Key Laboratory of Developmental Biology of Organs, Affiliated Hospital of Jinggangshan University, Ji'an, 343009, China. Electronic address: luhq2@126.com.
PMID: 33549839 DOI: 10.1016/j.envpol.2021.116539
Abstract

Bifenazate is a novel acaricide for selective foliar spraying and is widely used to control mites in agricultural production. However, its toxicity to aquatic organisms is unknown. Here, a zebrafish model was used to study bifenazate toxicity to aquatic organisms. Exposure to bifenazate was found to cause severe cardiotoxicity in zebrafish embryos, along with disorders in the gene expression related to heart development. Bifenazate also caused oxidative stress. Cardiotoxicity caused by bifenazate was partially rescued by astaxanthin (an antioxidant), accompanied by cardiac genes and oxidative stress-related indicators becoming normalized. Our results showed that exposure to bifenazate can significantly change the ATPase activity and gene expression levels of the calcium signaling pathway. These led to heart failure, in which the blood accumulated outside the heart without entering it, eventually leading to death. The results indicated that bifenazate exposure caused cardiotoxicity in zebrafish embryos through the induction of oxidative stress and inhibition of the calcium signaling pathway.

Keywords

Bifenazate; Calcium signaling pathway; Cardiotoxicity; Heart failure; Oxidative stress.

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