2. Academic Validation
  3. New butyrolactone derivatives from the endophytic Fungus Talaromyces sp. CPCC 400783 of Reynoutria japonica Houtt

New butyrolactone derivatives from the endophytic Fungus Talaromyces sp. CPCC 400783 of Reynoutria japonica Houtt

  • J Antibiot (Tokyo). 2021 Apr;74(4):225-232. doi: 10.1038/s41429-020-00388-w.
Ran Zhang # 1,  Wenni He # 1,  Yujia Wang 2,  JianYuan Zhao 2,  Rui Zhou 2,  Li Li 3,  Yize He 4,  Shan Cen 2,  Liyan Yu 5
Affiliations

Affiliations

  • 1 China Pharmaceutical Culture Collection, Institute of Medicinal Biotechnology, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing, 100050, China.
  • 2 Immunology Division, Institute of Medicinal Biotechnology, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing, 100050, China.
  • 3 Department of Medicinal Chemistry, Institute of Materia Medica, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing, 100050, China.
  • 4 College of Biochemical Engineering, Beijing Union University, Beijing, 100101, China.
  • 5 China Pharmaceutical Culture Collection, Institute of Medicinal Biotechnology, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing, 100050, China. yly@cpcc.ac.cn.
  • # Contributed equally.
PMID: 33361780 DOI: 10.1038/s41429-020-00388-w
Abstract

Six new butyrolactone derivatives (1, 2a/2b, 3a/3b and 4), together with another two known derivatives (5 and 6) were isolated from the endophytic fungus Talaromyces sp. CPCC 400783. Their structures were established by a combination of spectroscopic analysis, including NMR and HRESIMS. The absolute configurations were elucidated by ECD experiments. Subsequently, compound 1, 3b, 4 and 5 exhibited good inhibitory effect against influenza A/WSN/33 (H1N1) virus with IC50 values of 21.93 ± 1.51, 21.54 ± 3.75, 18.36 ± 2.15 and 23.80 ± 3.05 μM respectively.

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