2. Academic Validation
  3. Etamycin as a Novel Mycobacterium abscessus Inhibitor

Etamycin as a Novel Mycobacterium abscessus Inhibitor

  • Int J Mol Sci. 2020 Sep 21;21(18):6908. doi: 10.3390/ijms21186908.
Bui Thi Bich Hanh 1,  Tae Ho Kim 1,  June-Woo Park 2 3,  Da-Gyum Lee 1,  Jae-Sung Kim 4,  Young Eun Du 5,  Chul-Su Yang 6,  Dong-Chan Oh 5,  Jichan Jang 1
Affiliations

Affiliations

  • 1 Molecular Mechanisms of Antibiotics, Division of Life Science, Research Institute of Life Science, Division of Applied Life Science (BK21plus Program), Gyeongsang National University, Jinju 52828, Korea.
  • 2 Department of Environmental Toxicology and Chemistry, Korea Institute of Toxicology, Jinju 52843, Korea.
  • 3 Human and Environmental Toxicology Program, Korea University of Science and Technology (UST), Daejeon 34113, Korea.
  • 4 Institute of Natural Science & Technology, Hanyang University, Ansan 15588, Korea.
  • 5 Natural Products Research Institute, College of Pharmacy, Seoul National University, Seoul 08826, Korea.
  • 6 Department of Molecular & Life Science, Hanyang University, Ansan 15588, Korea.
PMID: 32967077 DOI: 10.3390/ijms21186908
Abstract

The increase in drug-resistant Mycobacterium abscessus, which has become resistant to existing standard-of-care agents, is a major concern, and new Antibacterial agents are strongly needed. In this study, we introduced etamycin that showed an excellent activity against M. abscessus. We found that etamycin significantly inhibited the growth of M. abscessus wild-type strain, three subspecies, and clinical isolates in vitro and inhibited the growth of M. abscessus that resides in macrophages without cytotoxicity. Furthermore, the in vivo efficacy of etamycin in the zebrafish (Danio rerio) Infection model was greater than that of clarithromycin, which is recommended as the core agent for treating M. abscessus infections. Thus, we concluded that etamycin is a potential anti-M. abscessus candidate for further development as a clinical drug candidate.

Keywords

Mycobacterium abscessus; drug resistance; novel drug discovery.

Figures
Products