2. Academic Validation
  3. Natural Bioactive Thiazole-Based Peptides from Marine Resources: Structural and Pharmacological Aspects

Natural Bioactive Thiazole-Based Peptides from Marine Resources: Structural and Pharmacological Aspects

  • Mar Drugs. 2020 Jun 24;18(6):329. doi: 10.3390/md18060329.
Rajiv Dahiya 1,  Sunita Dahiya 2,  Neeraj Kumar Fuloria 3,  Suresh Kumar 4,  Rita Mourya 5,  Suresh V Chennupati 6,  Satish Jankie 1,  Hemendra Gautam 7,  Sunil Singh 8,  Sanjay Kumar Karan 9,  Sandeep Maharaj 1,  Shivkanya Fuloria 3,  Jyoti Shrivastava 10,  Alka Agarwal 11,  Shamjeet Singh 1,  Awadh Kishor 12,  Gunjan Jadon 13,  Ajay Sharma 14
Affiliations

Affiliations

  • 1 School of Pharmacy, Faculty of Medical Sciences, The University of the West Indies, St. Augustine, Trinidad & Tobago.
  • 2 Department of Pharmaceutical Sciences, School of Pharmacy, University of Puerto Rico, Medical Sciences Campus, San Juan, PR 00936, USA.
  • 3 Department of Pharmaceutical Chemistry, Faculty of Pharmacy, AIMST University, Semeling, Bedong 08100, Kedah, Malaysia.
  • 4 Institute of Pharmaceutical Sciences, Kurukshetra University, Kurukshetra 136119, Haryana, India.
  • 5 School of Pharmacy, College of Medicine and Health Sciences, University of Gondar, P.O. Box 196, Gondar 6200, Ethiopia.
  • 6 Department of Pharmacy, College of Medical and Health Sciences, Wollega University, P.O. Box 395, Nekemte, Ethiopia.
  • 7 Arya College of Pharmacy, Dr. A.P.J. Abdul Kalam Technical University, Nawabganj, Bareilly 243407, Uttar Pardesh, India.
  • 8 Department of Pharmaceutical Chemistry, Ideal Institute of Pharmacy, Wada, Palghar 421303, Maharashtra, India.
  • 9 Department of Pharmaceutical Chemistry, Seemanta Institute of Pharmaceutical Sciences, Jharpokharia, Mayurbhanj 757086, Orissa, India.
  • 10 Department of Pharmaceutical Chemistry, The Oxford College of Pharmacy, Hongasandra, Bangalore 560068, Karnataka, India.
  • 11 Department of Pharmaceutical Chemistry, U.S. Ostwal Institute of Pharmacy, Mangalwad, Chittorgarh 313603, Rajasthan, India.
  • 12 Department of Pharmaceutical Biotechnology, Shrinathji Institute of Pharmacy, Nathdwara 313301, Rajsamand, Rajasthan, India.
  • 13 Department of Pharmaceutical Chemistry, Shrinathji Institute of Pharmacy, Nathdwara 313301, Rajsamand, Rajasthan, India.
  • 14 Department of Pharmacognosy and Phytochemistry, School of Pharmaceutical Sciences, Delhi Pharmaceutical Sciences and Research University, New Delhi 110017, India.
PMID: 32599909 DOI: 10.3390/md18060329
Abstract

Peptides are distinctive biomacromolecules that demonstrate potential cytotoxicity and diversified bioactivities against a variety of Microorganisms including bacteria, mycobacteria, and fungi via their unique mechanisms of action. Among broad-ranging pharmacologically active peptides, natural marine-originated thiazole-based oligopeptides possess peculiar structural features along with a wide spectrum of exceptional and potent bioproperties. Because of their complex nature and size divergence, thiazole-based peptides (TBPs) bestow a pivotal chemical platform in drug discovery processes to generate competent scaffolds for regulating allosteric binding sites and peptide-peptide interactions. The present study dissertates on the natural reservoirs and exclusive structural components of marine-originated TBPs, with a special focus on their most pertinent pharmacological profiles, which may impart vital resources for the development of novel peptide-based therapeutic agents.

Keywords

azole-based peptide; bioactivity; cyanobacteria; cytotoxicity; marine sponge; peptide synthesis; thiazole.

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