2. Academic Validation
  3. Serum lipids profiling perturbances in patients with ischemic heart disease and ischemic cardiomyopathy

Serum lipids profiling perturbances in patients with ischemic heart disease and ischemic cardiomyopathy

  • Lipids Health Dis. 2020 May 9;19(1):89. doi: 10.1186/s12944-020-01269-9.
Lin Yang 1,  Liang Wang 2,  Yangyang Deng 3,  Lizhe Sun 3,  Bowen Lou 3,  Zuyi Yuan 3,  Yue Wu 3,  Bo Zhou 4,  Junhui Liu 5,  Jianqing She 6
Affiliations

Affiliations

  • 1 Vascular surgery Department, First Affiliated Hospital of Xi'an Jiaotong University, Xi'an, China.
  • 2 Department of cardiovascular surgery, The general hospital of Ningxia Medical Univetsity, Yinchuan, China.
  • 3 Cardiovascular Department, First Affiliated Hospital of Medical College, Xi'an Jiaotong University, Xi'an, 710048, People's Republic of China.
  • 4 Respiratory Department, First Affiliated Hospital of Medical College, Xi'an Jiaotong University, Xi'an, 710048, People's Republic of China. zb_bob@163.com.
  • 5 Diagnostic Department, First Affiliated Hospital of Medical College, Xi'an Jiaotong University, Xi'an, 710048, People's Republic of China. liu1109@xjtu.edu.cn.
  • 6 Cardiovascular Department, First Affiliated Hospital of Medical College, Xi'an Jiaotong University, Xi'an, 710048, People's Republic of China. jianqingshe@xjtu.edu.cn.
PMID: 32386519 DOI: 10.1186/s12944-020-01269-9
Abstract

Background: Ischemic heart disease (IHD) is a common cardiovascular disorder associated with inadequate blood supply to the myocardium. Chronic coronary ischemia leads to ischemic cardiomyopathy (ICM). Despite their rising prevalence and morbidity, few studies have discussed the lipids alterations in these patients.

Methods: In this cross-sectional study, we analyzed serum lipids profile in IHD and ICM patients using a lipidomics approach. Consecutive consenting patients admitted to the hospital for IHD and ICM were enrolled. Serum samples were obtained after overnight fasting. Non-targeted metabolomics was applied to demonstrate lipids metabolic profile in control, IHD and ICM patients.

Results: A total of 63 and 62 lipids were detected in negative and positive ion mode respectively. Among them, 16:0 Lyso PI, 18:1 Lyso PI in negative ion mode, and 19:0 Lyso PC, 12:0 SM d18:1/12:0, 15:0 Lyso PC, 17:0 PC, 18:1-18:0 PC in positive ion mode were significantly altered both in IHD and ICM as compared to control. 13:0 Lyso PI, 18:0 Lyso PI, 16:0 PE, 14:0 PC DMPC, 16:0 ceramide, 18:0 ceramide in negative ion mode, and 17:0 PE, 19:0 PC, 14:0 Lyso PC, 20:0 Lyso PC, 18:0 PC DSPC, 18:0-22:6 PC in positive ion mode were significantly altered only in ICM as compared to IHD and control.

Conclusion: Using non-targeted lipidomics profiling, we have successfully identified a group of circulating lipids that were significantly altered in IHD and ICM. The lipids metabolic signatures shed light on potential new biomarkers and therapeutics for preventing and treating ICM.

Keywords

Biomarkers; Cardiovascular disorders; Ischemic cardiomyopathy; Ischemic heart disease; Lipidomics.

Figures
Products