Anti-inflammatory phenylpropanoid glycosides from the fruits of Forsythia suspensa

Bioorg Med Chem Lett. 2019 Oct 1;29(19):126635. doi: 10.1016/j.bmcl.2019.126635.

Si-Yuan Shao ¹, Ya-Nan Yang ¹, Zi-Ming Feng ¹, Jian-Shuang Jiang ¹, Pei-Cheng Zhang ²

Affiliations

1 State Key Laboratory of Bioactive Substances and Functions of Natural Medicines, Institute of Materia Medica, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing, PR China.
2 State Key Laboratory of Bioactive Substances and Functions of Natural Medicines, Institute of Materia Medica, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing, PR China. Electronic address: pczhang@imm.ac.cn.

PMID: 31473042 DOI: 10.1016/j.bmcl.2019.126635

Abstract

Five new phenylpropanoid glycosides, susaroysides A-E (1-5) were isolated from the fruits of Forsythia suspensa. Their structures were elucidated by comprehensive spectroscopic data analysis. The absolute configurations of their sugars were determined by GC analysis. Notably, susaroysides A-D possessed a sugar with an unsubstituted anomeric carbon, which is relatively rare in natural sources. Compound 1 exhibited significant anti-inflammatory activity against the lipopolysaccharide (LPS)-induced tumor necrosis factor (TNF)-α expression in macrophage cells with the IC₅₀ value of 1.053 μM.

Keywords

Anti-inflammatory activity; Forsythia suspensa; Phenylpropanoid glycosides; Susaroysides A–E; TNF-α.

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