2. Academic Validation
  3. Colletopeptides A-D, Anti-inflammatory Cyclic Tridepsipeptides from the Plant Endophytic Fungus Colletotrichum sp. S8

Colletopeptides A-D, Anti-inflammatory Cyclic Tridepsipeptides from the Plant Endophytic Fungus Colletotrichum sp. S8

  • J Nat Prod. 2019 Jun 28;82(6):1434-1441. doi: 10.1021/acs.jnatprod.8b00829.
Li Feng 1,  Jia Wang 1,  Shuai Liu 2,  Xue-Jia Zhang 1,  Qi-Rui Bi 1,  Yan-Yun Hu 1,  Zhe Wang 1,  Ning-Hua Tan 1
Affiliations

Affiliations

  • 1 Department of TCMs Pharmaceuticals, School of Traditional Chinese Pharmacy , China Pharmaceutical University , Nanjing 211198 , People's Republic of China.
  • 2 Faculty of Life Science and Food Engineering , Huaiyin Institute of Technology , Huaian 223001 , People's Republic of China.
PMID: 31181925 DOI: 10.1021/acs.jnatprod.8b00829
Abstract

Four new hybrid peptide-polyketide cyclic tridepsipeptides, colletopeptides A-D (1-4), were isolated and characterized from the endophytic fungus Colletotrichum sp. S8 derived from the stems of Rubia podantha with the guidance of LC-UV-MS detection. Their structures were elucidated by extensive spectroscopic analysis and X-ray crystallography. Compounds 1-4 are rare natural 12-membered cyclic tridepsipeptides containing a 3,5,11-trihydroxy-2-methyl dodecanoic acid unit in their structures. 1-4 inhibited lipopolysaccharide-induced nitric oxide production in RAW264.7 macrophages with the IC50 values of 8.3, 38.7, 13.5, and 22.2 μM, respectively. 1 also inhibited the production of inflammatory factors IL-6 and TNF-α, and decreased the phosphorylation of NF-κB-associated proteins IκBα and p65.

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