2. Academic Validation
  3. A new uridine derivative and a new indole derivative from the coral-associated actinomycete Pseudonocardia sp. SCSIO 11457

A new uridine derivative and a new indole derivative from the coral-associated actinomycete Pseudonocardia sp. SCSIO 11457

  • Nat Prod Res. 2021 Jan;35(2):188-194. doi: 10.1080/14786419.2019.1616729.
Zhuangjie Fang 1 2,  Siqiang Chen 1 2,  Yiguang Zhu 1,  Jie Li 1,  Imran Khan 1 2,  Qingbo Zhang 1,  Changsheng Zhang 1 2
Affiliations

Affiliations

  • 1 Key Laboratory of Tropical Marine Bio-resources and Ecology, Guangdong Key Laboratory of Marine Materia Medica, Institution of South China Sea Ecology and Environmental Engineering, South China Sea Institute of Oceanology, Chinese Academy of Sciences, Guangzhou, China.
  • 2 University of Chinese Academy of Sciences, Beijing, China.
PMID: 31137966 DOI: 10.1080/14786419.2019.1616729
Abstract

A new uridine derivative 11457 A (1), and a new indole derivative 11457B (2), together with a known compound 1H-indole-2-carbaldehyde (3), were characterized from the fermentation broth of the actinomycete Pseudonocardia sp. SCSIO 11457, an isolate associated with the scleractinian coral Galaxea fascicularis. Upon detailed spectroscopic analysis, 11457 A (1) was identified as a uridine analog, and 11457B (2) was elucidated as an indole derivative 2-hydroxy-1-(1H-indol-2-yl)pentane-1,4-dione. Biological evaluation indicated that none of compounds 1-3 showed Antibacterial activities against pathogenic bacteria and cytotoxic activities against human Cancer cell lines.

Keywords

Coral-associated actinomycete; Pseudonocardia sp.; marine natural products; uridine derivative.

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