2. Academic Validation
  3. Nickel(0)-catalyzed linear-selective hydroarylation of unactivated alkenes and styrenes with aryl boronic acids

Nickel(0)-catalyzed linear-selective hydroarylation of unactivated alkenes and styrenes with aryl boronic acids

  • Chem Sci. 2018 Jul 18;9(33):6839-6843. doi: 10.1039/c8sc02101e.
Honggui Lv 1,  Li-Jun Xiao 1,  Dongbing Zhao 1,  Qi-Lin Zhou 1
Affiliations

Affiliation

  • 1 State Key Laboratory and Institute of Elemento-Organic Chemistry , College of Chemistry , Nankai University , 94 Weijin Road , Tianjin 300071 , China . Email: dongbing.chem@nankai.edu.cn.
PMID: 30310616 DOI: 10.1039/c8sc02101e
Abstract

Herein, we describe the first linear-selective hydroarylation reaction of unactivated alkenes and styrenes with aryl boronic acids, which was achieved by introducing a directing group on the alkenes. This efficient, scalable reaction serves as a method for modular assembly of structurally diverse alkyl arenes, including γ-aryl butyric acid derivatives, which are widely utilized as chemical building blocks for the synthesis of various drugs and Other biologically active compounds.

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