2. Academic Validation
  3. Antifungal and Antiviral Cyclic Peptides from the Deep-Sea-Derived Fungus Simplicillium obclavatum EIODSF 020

Antifungal and Antiviral Cyclic Peptides from the Deep-Sea-Derived Fungus Simplicillium obclavatum EIODSF 020

  • J Agric Food Chem. 2017 Jun 28;65(25):5114-5121. doi: 10.1021/acs.jafc.7b01238.
Xiao Liang 1 2,  Xu-Hua Nong 1,  Zhong-Hui Huang 1 2,  Shu-Hua Qi 1
Affiliations

Affiliations

  • 1 Key Laboratory of Tropical Marine Bio-resources and Ecology/Guangdong Key Laboratory of Marine Materia Medica/RNAM Center for Marine Microbiology, South China Sea Institute of Oceanology, Chinese Academy of Sciences , 164 West Xingang Road, Guangzhou, 510301 Guangdong, China.
  • 2 University of Chinese Academy of Sciences , Beijing 100049, China.
PMID: 28578573 DOI: 10.1021/acs.jafc.7b01238
Abstract

A new linear peptide simplicilliumtide I (1) and four new cyclic peptides simplicilliumtides J-M (2-5) together with known analogues verlamelins A and B (6 and 7) were isolated from the deep-sea-derived Fungal strain Simplicillium obclavatum EIODSF 020. Their structures were elucidated by spectroscopic analysis, and their absolute configurations were further confirmed by chemical structural modification, Marfey's and Mosher's methods. Compounds 2, 6, and 7 showed significant Antifungal activity toward Aspergillus versicolor and Curvularia australiensis and also had obvious Antiviral activity toward HSV-1 with IC50 values of 14.0, 16.7, and 15.6 μM, respectively. The structure-bioactivity relationship of this type of cyclic peptide was also discussed. This is the first time to discuss the effects of the lactone linkage and the substituent group of the fatty acid chain fragment on the bioactivity of this type of cyclic peptides. This is also the first time to report the Antiviral activity of these cyclic peptides.

Keywords

Simplicillium obclavatum; antifungal; antiviral; deep-sea-derived fungus; peptide; structure−bioactivity relationship.

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