2. Academic Validation
  3. Kitamycin C, a new antimycin-type antibiotic from Streptomyces antibioticus strain 200-09

Kitamycin C, a new antimycin-type antibiotic from Streptomyces antibioticus strain 200-09

  • Nat Prod Res. 2017 Aug;31(15):1819-1824. doi: 10.1080/14786419.2017.1295240.
Fan Wang 1,  Shu-Na Fu 1,  Yi-Xuan Bao 1,  Yu Yang 1,  Hui-Fang Shen 2,  Bi-Run Lin 2,  Guang-Xiong Zhou 1
Affiliations

Affiliations

  • 1 a Guangdong Province Key Laboratory of Pharmacodynamic Constituents of Traditional Chinese Medicine and New Drugs Research , Institute of Traditional Chinese Medicine and Natural Products, College of Pharmacy, Jinan University , Guangzhou , China.
  • 2 b Key Laboratory of New Technique for Plant Protection in Guangdong , Institute of Plant Protection, Guangdong Academy of Agricultural Sciences , Guangzhou , China.
PMID: 28278640 DOI: 10.1080/14786419.2017.1295240
Abstract

An actinomycete strain 200-09, isolated from a soil sample collected from the coast of Hawaii, USA, was identified as Streptomyces antibioticus on the basis of its morphological, physiological and biochemical characteristics as well as 16S rDNA analysis. A new antimycin-type Antibiotic, kitamycin C (1), together with kitamycin A (2), kitamycin B (3), urauchmycin B (4), deisovaleryblastomycin (5) was isolated from a cultured broth of strain 200-09. The structure of the new compound was determined by spectroscopic data, including HR-ESI-MS and NMR. All the compounds exhibited Antifungal activities against Candida albicans with MIC of about 25.0 μg mL-1.

Keywords

Streptomyces antibioticus; antifungal activity; antimycin; kitamycin C.

Figures
Products
  • Cat. No.
    Product Name
    Description
    Target
    Research Area
  • HY-N14493
    Plant Growth Inhibitor