Lanostane Triterpenes Isolated from Antrodia heteromorpha and Their Inhibitory Effects on RANKL-Induced Osteoclastogenesis

J Nat Prod. 2016 Jun 24;79(6):1689-93. doi: 10.1021/acs.jnatprod.6b00207.

Jaeyoung Kwon, Hyaemin Lee, Yeo Dae Yoon ¹, Bang Yeon Hwang ², Yuanqiang Guo ³, Jong Soon Kang ¹, Jae-Jin Kim, Dongho Lee

Affiliations

1 Bio-Evaluation Center, Korea Research Institute of Bioscience and Biotechnology , Cheongju 28116, Republic of Korea.
2 College of Pharmacy, Chungbuk National University , Cheongju 28644, Republic of Korea.
3 State Key Laboratory of Medicinal Chemical Biology, College of Pharmacy, and Tianjin Key Laboratory of Molecular Drug Research, Nankai University , Tianjin 300353, People's Republic of China.

PMID: 27266877 DOI: 10.1021/acs.jnatprod.6b00207

Abstract

Two new spiro-lanostane triterpenoids, antrolactones A and B (1 and 2), along with polyporenic acid C (3), were isolated from an EtOAc-soluble extract of Antrodia heteromorpha culture medium, and the chemical structures of the new compounds were elucidated by application of NMR, MS, and ECD spectroscopic techniques. All isolated compounds exhibited inhibitory effects on receptor activator of nuclear factor-kappaB ligand-induced osteoclastogenesis.

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