2. Academic Validation
  3. Organization, evolution and functions of the human and mouse Ly6/uPAR family genes

Organization, evolution and functions of the human and mouse Ly6/uPAR family genes

  • Hum Genomics. 2016 Apr 21:10:10. doi: 10.1186/s40246-016-0074-2.
Chelsea L Loughner 1,  Elspeth A Bruford 2,  Monica S McAndrews 3,  Emili E Delp 1,  Sudha Swamynathan 1,  Shivalingappa K Swamynathan 4 5 6 7 8
Affiliations

Affiliations

  • 1 Department of Ophthalmology, University of Pittsburgh School of Medicine, Pittsburgh, USA.
  • 2 HUGO Gene Nomenclature Committee (HGNC), European Bioinformatics Institute (EMBL-EBI), Wellcome Genome Campus, Hinxton, Cambridgeshire, CB10 1SD, UK.
  • 3 Mouse Genome Informatics, The Jackson Laboratory, Bar Harbor, ME, 04609, USA.
  • 4 Department of Ophthalmology, University of Pittsburgh School of Medicine, Pittsburgh, USA. Swamynathansk@upmc.edu.
  • 5 Department of Cell Biology, University of Pittsburgh School of Medicine, Pittsburgh, USA. Swamynathansk@upmc.edu.
  • 6 McGowan Institute of Regenerative Medicine, University of Pittsburgh, Pittsburgh, USA. Swamynathansk@upmc.edu.
  • 7 Fox Center for Vision Restoration, University of Pittsburgh School of Medicine, Pittsburgh, USA. Swamynathansk@upmc.edu.
  • 8 Eye and Ear Institute, University of Pittsburgh School of Medicine, 203 Lothrop Street, Room 1025, Pittsburgh, PA, 15213, USA. Swamynathansk@upmc.edu.
PMID: 27098205 DOI: 10.1186/s40246-016-0074-2
Abstract

Members of the lymphocyte antigen-6 (Ly6)/urokinase-type plasminogen activator receptor (uPAR) superfamily of proteins are cysteine-rich proteins characterized by a distinct disulfide bridge pattern that creates the three-finger Ly6/uPAR (LU) domain. Although the Ly6/uPAR family proteins share a common structure, their expression patterns and functions vary. To date, 35 human and 61 mouse Ly6/uPAR family members have been identified. Based on their subcellular localization, these proteins are further classified as GPI-anchored on the cell membrane, or secreted. The genes encoding Ly6/uPAR family proteins are conserved across different species and are clustered in syntenic regions on human chromosomes 8, 19, 6 and 11, and mouse Chromosomes 15, 7, 17, and 9, respectively. Here, we review the human and mouse Ly6/uPAR family gene and protein structure and genomic organization, expression, functions, and evolution, and introduce new names for novel family members.

Keywords

LU domain; Ly6/uPAR family; Lymphocytes; Neutrophils; Three-finger domain; uPAR.

Figures
Products