2. Academic Validation
  3. Steroidal Glucosides from the Rhizomes of Tacca chantrieri and Their Inhibitory Activities of NO Production in BV2 Cells

Steroidal Glucosides from the Rhizomes of Tacca chantrieri and Their Inhibitory Activities of NO Production in BV2 Cells

  • Nat Prod Commun. 2016 Jan;11(1):45-8.
Pham Hai Yen,  Vu Thi Quynh Chi,  Dong-Cheol Kim,  Wonmin Ko,  Hyuncheol Oh,  Youn-Chul Kim,  Duong Thi Dung,  Nguyen Thi Viet Thanh,  Tran Hong Quang,  Nguyen Thi Thanh Ngan,  Nguyen Xuan Nhiema,  Hoang Le Tuan Anh,  Chan Van Minh,  Phan Van Kiem
PMID: 26996017
Abstract

Two new steroidal glucosides, chantriolides D and E (1 and 2), along with four known compounds, chantriolide A (3), chantriolide B (4), chantriolide C (5), and (25S)-spirost-5-en-3-ol 3-O-α-L-rhamnopyranosyl-(1-->2)-O-[α-L-rhamnopyranosyl-(1-->3)]-β-D-glucopyranoside (6) were isolated from the rhizomes of Tacca chantrieri. Their structures were determined by 1D and 2D NMR spectroscopic and HR-ESI-MS data, as well as by comparison with reported data. Compounds 1 and 2 were found to show strong inhibitory NO effect in BV2 cells, with IC₅₀ values of 12.45 and 59.03 µM, respectively.

Figures
Products