2. Academic Validation
  3. Synthesis and structural characterization of natural benzofuranoids

Synthesis and structural characterization of natural benzofuranoids

  • J Nat Prod. 2015 May 22;78(5):1056-66. doi: 10.1021/np5010483.
Kouji Kuramochi 1,  Kazunori Tsubaki 1
Affiliations

Affiliation

  • 1 Graduate School of Life and Environmental Sciences, Kyoto Prefectural University, Sakyo-ku, Kyoto 606-8522, Japan.
PMID: 25906402 DOI: 10.1021/np5010483
Abstract

The synthesis of ustusoranes A, B, and E, pergillin, dihydropergillin, (±)-penicisochroman A, and (-)-brassicadiol, starting from optically active (R)-benzolactone, is described. The synthesis of ustusoranes A and E established the absolute configurations of these natural products. The synthesis of pergillin and (±)-penicisochroman A led to the structural revision of aspergiones E and F. This study clearly indicates that (R)-benzolactone is a potential intermediate in the synthesis of natural benzofuranoids.

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