2. Academic Validation
  3. Identification of mureidomycin analogues and functional analysis of an N-acetyltransferase in napsamycin biosynthesis

Identification of mureidomycin analogues and functional analysis of an N-acetyltransferase in napsamycin biosynthesis

  • Chembiochem. 2013 Nov 25;14(17):2248-55. doi: 10.1002/cbic.201300287.
Xiaoyu Tang 1,  Marcel Gross,  Yunying Xie,  Andreas Kulik,  Bertolt Gust
Affiliations

Affiliation

  • 1 Pharmaceutical Institute, University of Tuebingen, Auf der Morgenstelle 8, 72076 Tübingen (Germany).
PMID: 24115404 DOI: 10.1002/cbic.201300287
Abstract

Antibiotic abundance: Several new uridyl peptide Antibiotics were identified from a heterologous producer strain containing the mureidomycin/napsamycin biosynthetic gene cluster by using HRMS and LC-ESI-MS/MS. Analysis of the new compounds and the corresponding gene cluster revealed NpsB, an N-acetyltransferase, to be responsible for acetylation of the uridyl peptide Antibiotic.

Keywords

N-acetylation; biosynthesis; heterologous expression; uridyl peptide antibiotics.

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