2. Academic Validation
  3. Anti-proliferative activity of hydnocarpin, a natural lignan, is associated with the suppression of Wnt/β-catenin signaling pathway in colon cancer cells

Anti-proliferative activity of hydnocarpin, a natural lignan, is associated with the suppression of Wnt/β-catenin signaling pathway in colon cancer cells

  • Bioorg Med Chem Lett. 2013 Oct 15;23(20):5511-4. doi: 10.1016/j.bmcl.2013.08.065.
Min-Ai Lee 1,  Won Kyung Kim,  Hyen Joo Park,  Sam Sik Kang,  Sang Kook Lee
Affiliations

Affiliation

  • 1 College of Pharmacy, Natural Products Research Institute, Seoul National University, San 56-1 Sillim-dong, Gwanak-gu, Seoul 151-741, Republic of Korea.
PMID: 24018191 DOI: 10.1016/j.bmcl.2013.08.065
Abstract

Based on the Wnt inhibitors as potential targets in the development of Anticancer agents, natural compounds were evaluated for β-catenin-mediated transcriptional activity. A natural lignan hydnocarpin isolated from Lonicera japonica was considered a potential inhibitor for Wnt/β-catenin signalings. The anti-proliferative activity of hydnocarpin was also found to be associated with the suppression of Wnt/β-catenin-mediated signaling pathway in human colon Cancer cells. These data suggest that hydnocarpin might be a novel Wnt Inhibitor and has a potential of signaling regulator in β-catenin-mediated signaling pathways.

Keywords

Anti-proliferation; Axin turnover; Colon cancer cells; Hydnocarpin; Wnt/beta-catenin.

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