2. Academic Validation
  3. Extracellular lipid metabolism influences the survival of ovarian cancer cells

Extracellular lipid metabolism influences the survival of ovarian cancer cells

  • Biochem Biophys Res Commun. 2013 Sep 20;439(2):280-4. doi: 10.1016/j.bbrc.2013.08.041.
Shohei Kuwata 1,  Kei Ohkubo,  Shun Kumamoto,  Naoto Yamaguchi,  Naoki Izuka,  Kaeko Murota,  Toshifumi Tsujiuchi,  Masao Iwamori,  Nobuyuki Fukushima
Affiliations

Affiliation

  • 1 Division of Molecular Neurobiology, Department of Life Science, School of Science and Engineering, Kinki University, Higashiosaka, Japan.
PMID: 23973712 DOI: 10.1016/j.bbrc.2013.08.041
Abstract

Lysophosphatidic acid (LPA) is an extracellular lipid mediator consisting of a fatty acid and a phosphate group linked to the glycerol backbone. Here, we show that 1-oleoyl- and 1-palmitoyl-LPA, but not 1-stearoyl- or alkyl-LPA, enhance HNOA ovarian Cancer cell survival. Other lysophospholipids with oleic or lauric acid, but not stearic acid, also induce the survival effects. HNOA cells have the Lipase activities that cleave LPA to generate fatty acid. Oleic acid stimulates HNOA cell survival via increased glucose utilization. Our findings suggest that extracellular lysolipid metabolism might play an important role in HNOA cell growth.

Keywords

Cell survival; Fatty acid; Lysophosphatidic acid; Lysophospholipase; Ovarian cancer cell.

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