2. Academic Validation
  3. Virtual screening and experimental validation reveal novel small-molecule inhibitors of 14-3-3 protein-protein interactions

Virtual screening and experimental validation reveal novel small-molecule inhibitors of 14-3-3 protein-protein interactions

  • Chem Commun (Camb). 2013 Oct 4;49(76):8468-70. doi: 10.1039/c3cc44612c.
Philipp Thiel 1,  Lars Röglin,  Nicole Meissner,  Sven Hennig,  Oliver Kohlbacher,  Christian Ottmann
Affiliations

Affiliation

  • 1 Chemical Genomics Centre of the Max Planck Society, Otto-Hahn-Straße 15, D-44227 Dortmund, Germany.
PMID: 23939230 DOI: 10.1039/c3cc44612c
Abstract

We report first non-covalent and exclusively extracellular inhibitors of 14-3-3 protein-protein interactions identified by virtual screening. Optimization by crystal structure analysis and in vitro binding assays yielded compounds capable of disrupting the interaction of 14-3-3σ with Aminopeptidase N in a cellular assay.

Figures
Products
  • Cat. No.
    Product Name
    Description
    Target
    Research Area
  • HY-177590
    14-3-3 Protein Inhibitor
    MMP