2. Academic Validation
  3. Anti-influenza virus polyketides from the acid-tolerant fungus Penicillium purpurogenum JS03-21

Anti-influenza virus polyketides from the acid-tolerant fungus Penicillium purpurogenum JS03-21

  • J Nat Prod. 2011 Sep 23;74(9):2014-8. doi: 10.1021/np2004769.
Hui Wang 1,  Yi Wang,  Wei Wang,  Peng Fu,  Peipei Liu,  Weiming Zhu
Affiliations

Affiliation

  • 1 Key Laboratory of Marine Drugs, Chinese Ministry of Education, School of Medicine and Pharmacy, Ocean University of China, Qingdao 266003, People's Republic of China.
PMID: 21879714 DOI: 10.1021/np2004769
Abstract

Fractionation of the ethyl acetate extract of an acid-tolerant fungus, Penicillium purpurogenum JS03-21, resulted in the isolation of six new compounds, purpurquinones A-C (1-3), purpuresters A and B (4 and 5), and 2,6,7-trihydroxy-3-methylnaphthalene-1,4-dione (6), together with three known compounds, TAN-931 (7), (-)-mitorubrin (8), and orsellinic acid. The structures of 1-6 were elucidated primarily by NMR experiments. The absolute configurations of 1-4 were assigned on the basis of CD and NOESY data. Compounds 2-4 and 7 exhibited significant Antiviral activity against H1N1, with IC50 values of 61.3, 64.0, 85.3, and 58.6 μM, respectively.

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