2. Academic Validation
  3. Triazole and dihydroimidazole alkaloids from the marine sediment-derived fungus Penicillium paneum SD-44

Triazole and dihydroimidazole alkaloids from the marine sediment-derived fungus Penicillium paneum SD-44

  • J Nat Prod. 2011 May 27;74(5):1331-4. doi: 10.1021/np200037z.
Chun-Shun Li 1,  Chun-Yan An,  Xiao-Ming Li,  Shu-Shan Gao,  Chuan-Ming Cui,  Hao-Fen Sun,  Bin-Gui Wang
Affiliations

Affiliation

  • 1 Key Laboratory of Experimental Marine Biology, Institute of Oceanology, Chinese Academy of Sciences, Nanhai Road 7, Qingdao 266071, People's Republic of China.
PMID: 21495659 DOI: 10.1021/np200037z
Abstract

A novel triazole carboxylic acid, penipanoid A (1), two new quinazolinone Alkaloids, penipanoids B (2) and C (3), and a very recently reported quinazolinone derivative (4) were isolated from the marine sediment-derived fungus Penicillium paneum SD-44. Their structures were elucidated by spectroscopic analysis, and the structure for 1 was confirmed by X-ray crystallographic analysis. Compound 1 represents the first example of a triazole derivative from marine sediment-derived fungi, and compound 2 is a rare quinazolinone derivative having a dihydroimidazole ring system. The cytotoxicity of compounds 1 and 4 and the antimicrobial activity of 1-4 were evaluated.

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