2. Academic Validation
  3. Synthesis and biological evaluation of benzyl styrylsulfonyl derivatives as potent anticancer mitotic inhibitors

Synthesis and biological evaluation of benzyl styrylsulfonyl derivatives as potent anticancer mitotic inhibitors

  • Bioorg Med Chem Lett. 2011 May 15;21(10):3066-9. doi: 10.1016/j.bmcl.2011.03.041.
Osama Chahrour 1,  Ashraf Abdalla,  Frankie Lam,  Carol Midgley,  Shudong Wang
Affiliations

Affiliation

  • 1 School of Pharmacy and Centre for Biomolecular Sciences, University of Nottingham, Nottingham NG7 2RD, UK.
PMID: 21463944 DOI: 10.1016/j.bmcl.2011.03.041
Abstract

We herein report the synthesis, biological activity and structure activity relationship of derivatives of benzylstyrylsulfone, benzylstyrylsulfine and benzylsulfonyl-N-phenylacetamide. A lead compound 7 represents a new class of mitotic inhibitors that demonstrates potent anti-proliferative activity and selectively induces Cancer cell Apoptosis while sparing non-transformed lung fibroblast.

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