2. Academic Validation
  3. Novel synthesis of hydrazide-hydrazone derivatives and their utilization in the synthesis of coumarin, pyridine, thiazole and thiophene derivatives with antitumor activity

Novel synthesis of hydrazide-hydrazone derivatives and their utilization in the synthesis of coumarin, pyridine, thiazole and thiophene derivatives with antitumor activity

  • Molecules. 2010 Dec 23;16(1):16-27. doi: 10.3390/molecules16010016.
Rafat M Mohareb 1,  Daisy H Fleita,  Ola K Sakka
Affiliations

Affiliation

  • 1 Department of Organic Chemistry, Faculty of Pharmacy, October University for Modern Sciences and Arts, October City, A.R., Egypt. raafat_mohareb@yahoo.com
PMID: 21187814 DOI: 10.3390/molecules16010016
Abstract

The reaction of cyanoacetyl hydrazine (1) with 3-acetylpyridine (2) gave the hydrazide-hydrazone derivative 3. The latter compound undergoes a series of heterocyclization reactions to give new heterocyclic compounds. The antitumor evaluation of the newly synthesized products against three Cancer cell lines, namely breast adenocarcinoma (MCF-7), non-small cell lung Cancer (NCI-H460) and CNS Cancer (SF-268) was performed. Most of the synthesized compounds showed high inhibitory effects.

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