2. Academic Validation
  3. Identification of biphenyl-based hybrid molecules able to decrease the intracellular level of Bcl-2 protein in Bcl-2 overexpressing leukemia cells

Identification of biphenyl-based hybrid molecules able to decrease the intracellular level of Bcl-2 protein in Bcl-2 overexpressing leukemia cells

  • J Med Chem. 2009 Nov 12;52(21):6936-40. doi: 10.1021/jm900907s.
Daniela Pizzirani 1,  Marinella Roberti,  Stefania Grimaudo,  Antonietta Di Cristina,  Rosaria Maria Pipitone,  Manlio Tolomeo,  Maurizio Recanatini
Affiliations

Affiliation

  • 1 Department of Chemistry and Chemical Biology, Harvard University and the Broad Institute of MIT and Harvard, Cambridge, Massachusetts 02138, USA.
PMID: 19764793 DOI: 10.1021/jm900907s
Abstract

With the aim of enhancing the structural complexity and diversity of an existing collection of bi- and terphenyl compounds, we synthesized hybrid molecules comprising of spirocyclic ketones (a complexity-bearing core) and bi/terphenyls (privileged fragments). Compounds 1, 3, 4, and 6 showed well-defined activity on Apoptosis and differentiation, making them potential leads for development as new Anticancer agents and chemical probes to study signaling networks in neoplastic cells.

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