2. Academic Validation
  3. Fluvirucins A1, A2, B1, B2, B3, B4 and B5, new antibiotics active against influenza A virus. II. Structure determination

Fluvirucins A1, A2, B1, B2, B3, B4 and B5, new antibiotics active against influenza A virus. II. Structure determination

  • J Antibiot (Tokyo). 1991 Jul;44(7):741-55. doi: 10.7164/antibiotics.44.741.
N Naruse 1,  T Tsuno,  Y Sawada,  M Konishi,  T Oki
Affiliations

Affiliation

  • 1 Bristol-Myers Squibb Research Institute, Tokyo, Japan.
PMID: 1880064 DOI: 10.7164/antibiotics.44.741
Abstract

A series of structurally related antiviral Antibiotics, fluvirucins A1, A2, B1, B2, B3, B4 and B5 have been isolated from the fermentation broths of five unidentified actinomycete isolates. Based on spectroscopic analysis, partial degradation experiments and 13C-enriched acetic acid-fed biosynthetic studies, their structures were elucidated to be 2.6,10-trialkyl-3(or 9)-aminoglycosyl-13-tridecanelactams.

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