2. Academic Validation
  3. The berkeleyamides, amides from the acid lake fungus Penicillum rubrum

The berkeleyamides, amides from the acid lake fungus Penicillum rubrum

  • J Nat Prod. 2008 May;71(5):856-60. doi: 10.1021/np0705054.
Andrea A Stierle 1,  Donald B Stierle,  Brianna Patacini
Affiliations

Affiliation

  • 1 Department of Chemistry and Geochemistry, Montana Tech of the University of Montana, Butte, MT 59701, USA. astierle@mtech.edu
PMID: 18330993 DOI: 10.1021/np0705054
Abstract

We previously reported several novel bioactive hybrid polyketide-terpenoid metabolites from a deep water Penicillium rubrum isolated from Berkeley Pit Lake, Butte, Montana. In this paper we report the structures of four new amides, berkeleyamides A-D (1, 4, 5, 7), isolated from extracts of this fungus. The structures of these compounds were deduced by analysis of NMR data, chemical derivatization, and comparison of their spectroscopic data to those of known compounds.

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