2. Academic Validation
  3. Synthesis of novel spirostanic saponins and their cytotoxic activity

Synthesis of novel spirostanic saponins and their cytotoxic activity

  • Bioorg Med Chem. 2008 Feb 15;16(4):2063-76. doi: 10.1016/j.bmc.2007.10.089.
Juan C Hernández 1,  Francisco León,  Ignacio Brouard,  Fernando Torres,  Sara Rubio,  José Quintana,  Francisco Estévez,  Jaime Bermejo
Affiliations

Affiliation

  • 1 Instituto de Productos Naturales y Agrobiología-C.S.I.C., Antonio González, Av. Astrofísico F. Sánchez 3, 38206 La Laguna, Tenerife, Spain.
PMID: 18023191 DOI: 10.1016/j.bmc.2007.10.089
Abstract

This study was carried out to assess the cytotoxicity of several new synthetic steroidal saponins against the human myeloid leukemia cell lines (HL-60 and U937) and against human melanoma cells (SK-MEL-1). Several diosgenyl glycosides analyzed showed strong cell growth inhibition which was associated with alterations in cell cycle progression and induction of Apoptosis. Studies of cytochrome c release and caspase-9 activation suggest a main role of the intrinsic pathway of Apoptosis in the mechanism of cytotoxicity caused by this kind of compounds.

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