2. Academic Validation
  3. Antiproliferative ent-Kauranoids from Isodon parvifolius

Antiproliferative ent-Kauranoids from Isodon parvifolius

  • Planta Med. 2006 Jun;72(8):740-5. doi: 10.1055/s-2006-931608.
Li-Mei Li 1,  Guo-You Li,  Sheng-Xiong Huang,  Wei-Lie Xiao,  Xun Liao,  Li-Guang Lou,  Li-Sheng Ding,  Han-Dong Sun
Affiliations

Affiliation

  • 1 State Key Laboratory of Phytochemistry and Plant Resources in West China, Kunming Institute of Botany, Chinese Academy of Sciences, Kunming, P. R. China.
PMID: 16732517 DOI: 10.1055/s-2006-931608
Abstract

Nine new 7alpha,20-epoxy- ENT-kaurane Diterpenoids, parvifolines O - W (1 - 9), together with five known analogues, lasiocarpanin (10), rosthorin A (11), longikaurin E (12), adenolin D (13) and longikaurin B (14), were isolated from the leaves of Isodon parvifolius. Their structures were determined by means of spectroscopic analysis. Selected Diterpenoids (1 - 10) were tested for their antiproliferative activity against A549, HT-29 and K562 cells. Compounds 3, 7, 8 and 10 showed moderate inhibitory activity against all three cell lines.

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