2. Academic Validation
  3. Sundaicumones A and B, polyprenylated acylphloroglucinol derivatives from Calophyllumsundaicum with weak activity against the glucocorticoid receptor

Sundaicumones A and B, polyprenylated acylphloroglucinol derivatives from Calophyllumsundaicum with weak activity against the glucocorticoid receptor

  • J Nat Prod. 2006 Apr;69(4):707-9. doi: 10.1021/np050528n.
Shugeng Cao 1,  Kia-Ngee Low,  Robert P Glover,  Sharon C Crasta,  Siewbee Ng,  Antony D Buss,  Mark S Butler
Affiliations

Affiliation

  • 1 MerLion Pharmaceuticals, 1 Science Park Road, The Capricorn #05-01, Singapore Science Park II, Singapore 117528.
PMID: 16643060 DOI: 10.1021/np050528n
Abstract

Bioassay-directed fractionation using a Glucocorticoid Receptor assay led to the isolation of two new, weakly active polyprenylated acylphloroglucinol derivatives, sundaicumones A (1) and B (2), from the leaves of Calophyllum sundaicum collected in Singapore. The structures of 1 and 2, which were established by spectroscopic methods, contain a 3-substituted hexanoic acid unit not previously reported in Other polyprenylated acylphloroglucinols.

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