2. Academic Validation
  3. Modulators of the human CCR5 receptor. Part 1: Discovery and initial SAR of 1-(3,3-diphenylpropyl)-piperidinyl amides and ureas

Modulators of the human CCR5 receptor. Part 1: Discovery and initial SAR of 1-(3,3-diphenylpropyl)-piperidinyl amides and ureas

  • Bioorg Med Chem Lett. 2005 Jan 3;15(1):25-8. doi: 10.1016/j.bmcl.2004.10.044.
Jeremy N Burrows 1,  John G Cumming,  Shaun M Fillery,  Gordon A Hamlin,  Julian A Hudson,  Ruth J Jackson,  Sharon McLaughlin,  John S Shaw
Affiliations

Affiliation

  • 1 Respiratory and Inflammation Research Area, AstraZeneca, Mereside, Alderley Park, Macclesfield, Cheshire, SK10 4TG, UK.
PMID: 15582404 DOI: 10.1016/j.bmcl.2004.10.044
Abstract

Investigation of weak screening hits led to the identification of N-alkyl-N-[1-(3,3-diphenylpropyl)piperidin-4-yl]-2-phenylacetamides and N-alkyl-N-[1-(3,3-diphenylpropyl)piperidin-4-yl]-N'-benzylureas as potent, selective ligands for the human CCR5 Chemokine Receptor.

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