2. Academic Validation
  3. Kigamicins, novel antitumor antibiotics. II. Structure determination

Kigamicins, novel antitumor antibiotics. II. Structure determination

  • J Antibiot (Tokyo). 2003 Dec;56(12):1012-7. doi: 10.7164/antibiotics.56.1012.
Setsuko Kunimoto 1,  Tetsuya Someno,  Yohko Yamazaki,  Jie Lu,  Hiroyasu Esumi,  Hiroshi Naganawa
Affiliations

Affiliation

  • 1 Microbial Chemistry Research Center, Numazu Bio-Medical Research Institute, 18-24 Miyamoto, Numazu-shi, Shizuoka 410-0301, Japan. kunimotos@bikaken.or.jp
PMID: 15015728 DOI: 10.7164/antibiotics.56.1012
Abstract

Kigamicin A (1), B (2), C (3), D (4) and E (5) are novel antitumor Antibiotics. Their structures were determined by spectroscopic analyses including various NMR measurements. Kigamicins have a unique aglycone of fused octacyclic ring system containing seven of six-membered rings and one oxazolidine. The aglycone links a sugar chain composed of one to four deoxysugars. These sugars were found to be amicetose and oleandrose.

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