2. Academic Validation
  3. Melanocins A, B and C, new melanin synthesis inhibitors produced by Eupenicillium shearii. I. Taxonomy, fermentation, isolation and biological properties

Melanocins A, B and C, new melanin synthesis inhibitors produced by Eupenicillium shearii. I. Taxonomy, fermentation, isolation and biological properties

  • J Antibiot (Tokyo). 2003 Dec;56(12):993-9. doi: 10.7164/antibiotics.56.993.
Jong-Pyung Kim 1,  Byoung-Kwon Kim,  Bong-Sik Yun,  In-Ja Ryoo,  Choong Hwan Lee,  In-Kyoung Lee,  Won-Gon Kim,  Sangku Lee,  Yu-Ryang Pyun,  Ick-Dong Yoo
Affiliations

Affiliation

  • 1 Korea Research Institute of Bioscience and Biotechnology, Yuseong, Daejeon 305-600, Korea.
PMID: 15015725 DOI: 10.7164/antibiotics.56.993
Abstract

New melanin synthesis inhibitors, melanocins A, B and C, were isolated from the fermentation broth and mycelium extract of Eupenicillium shearii F80695. Melanocin A, an isocyanide compound, inhibited mushroom Tyrosinase and melanin biosynthesis of B16 melanoma cells with IC50 value of 9.0 nM and MIC value of 0.9 microM, respectively. Melanocin A also inhibited growth of Streptomyces bikiniensis. While, the structurally very related but non-isocyanide compounds melanocins B and C did not show inhibitory activity in these assays. Melanocins A, B and C showed potent antioxidant activity with scavenging activity of DPPH radical and superoxide anion radical.

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