2. Academic Validation
  3. Psammaplin A, a marine natural product, inhibits aminopeptidase N and suppresses angiogenesis in vitro

Psammaplin A, a marine natural product, inhibits aminopeptidase N and suppresses angiogenesis in vitro

  • Cancer Lett. 2004 Jan 20;203(2):163-9. doi: 10.1016/j.canlet.2003.08.036.
Joong Sup Shim 1,  Hyi-Seung Lee,  Jongheon Shin,  Ho Jeong Kwon
Affiliations

Affiliation

  • 1 Department of Bioscience and Biotechnology, Institute of Bioscience, Sejong University, 98 Kunja-dong Kwangjin-gu, Seoul 143-747, South Korea.
PMID: 14732224 DOI: 10.1016/j.canlet.2003.08.036
Abstract

Psammaplin A (PsA) is a phenolic natural product isolated from a marine Sponge, which showed a potent cytotoxicity against several Cancer cell lines. In present study, PsA was found to inhibit mammalian Aminopeptidase N (APN) that plays a key role in tumor cell invasion and angiogenesis. PsA inhibited the APN activity with an IC50 of 18 microM in a non-competitive manner. Moreover, PsA potently inhibited the proliferation of several Cancer and endothelial cells. Interestingly, the anti-proliferative effect of PsA was dependent on the cellular amount of APN expression. Finally, PsA suppressed the invasion and tube formation of endothelial cells stimulated by basic Fibroblast Growth Factor. These data demonstrate that PsA is a new inhibitor of APN and can be developed as a novel anti-angiogenic agent.

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