2. Academic Validation
  3. Seitomycin: isolation, structure elucidation and biological activity of a new angucycline antibiotic from a terrestrial Streptomycete

Seitomycin: isolation, structure elucidation and biological activity of a new angucycline antibiotic from a terrestrial Streptomycete

  • J Antibiot (Tokyo). 2003 Jun;56(6):539-42. doi: 10.7164/antibiotics.56.539.
Mohamed Abdelfattah 1,  Rajendra P Maskey,  Ratnakar N Asolkar,  Iris Grün-Wollny,  Hartmut Laatsch
Affiliations

Affiliation

  • 1 Department of Organic Chemistry, University of Göttingen, Tammanstrasse 2, Göttingen D-37077, Germany.
PMID: 12931863 DOI: 10.7164/antibiotics.56.539
Abstract

A new Antibiotic, named seitomycin (1c), and the known microbial metabolite tetrangulol methyl ether (2) were found in the ethyl acetate extract of two terrestrial Streptomyces sp. isolates. The structure of the new Antibiotic was elucidated by spectroscopic studies and by comparison of the NMR data with the structurally related hatomarubigin C (1a) and SM-196 B (1b). Seitomycin (1c) showed moderate antimicrobial and weak phytotoxic activity, similar to tetrangulol methyl ether (2).

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