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  3. Intrinsic resistance of Escherichia coli to mureidomycin A and C due to expression of the multidrug efflux system AcrAB-TolC: comparison with the efflux systems of mureidomycin-susceptible Pseudomonas aeruginosa

Intrinsic resistance of Escherichia coli to mureidomycin A and C due to expression of the multidrug efflux system AcrAB-TolC: comparison with the efflux systems of mureidomycin-susceptible Pseudomonas aeruginosa

  • J Infect Chemother. 2003 Mar;9(1):101-3. doi: 10.1007/s10156-002-0205-2.
Naomasa Gotoh 1,  Takeshi Murata,  Toru Ozaki,  Tadashi Kimura,  Akiko Kondo,  Takeshi Nishino
Affiliations

Affiliation

  • 1 Department of Microbiology, Kyoto Pharmaceutical University, 5 Misasaginakauchi-cho, Yamashina-ku, Kyoto 607-8414, Japan. ngotoh@mb.kyoto-phu.ac.jp
PMID: 12673418 DOI: 10.1007/s10156-002-0205-2
Abstract

Intrinsic resistance to mureidomycin is shown in Escherichia coli. This is in contrast to Pseudomonas aeruginosa, which generally displays intrinsic resistance to a variety of antimicrobial agents, but not to mureidomycin. Isogenic efflux system mutants from both species were subjected to Antibiotic susceptibility tests. These studies showed that the differences regarding the susceptibility of E. coli and P. aeruginosa to mureidomycin A and C may be explained by the expression of efflux systems that mediate resistance to mureidomycin A and C.

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