2. Academic Validation
  3. Synthesis of milbemycins alpha9, alpha10, alpha11, alpha12, alpha14, alpha15, alpha20, alpha21, alpha22, alpha23, alpha26, alpha27, delta(2,3),delta(4,26)-milbemycins A3, A4 from milbemycins A3, A4, and their acaricidal activities

Synthesis of milbemycins alpha9, alpha10, alpha11, alpha12, alpha14, alpha15, alpha20, alpha21, alpha22, alpha23, alpha26, alpha27, delta(2,3),delta(4,26)-milbemycins A3, A4 from milbemycins A3, A4, and their acaricidal activities

  • J Antibiot (Tokyo). 2002 Nov;55(11):993-1003. doi: 10.7164/antibiotics.55.993.
Takahiro Tsukiyama 1,  Hisaki Kajino,  Fumie Kajino,  Satoru Furuta,  Yoshihisa Tsukamoto,  Kazuo Sato,  Ayako Kinoshita,  Reiji Ichinose,  Keiji Tanaka
Affiliations

Affiliation

  • 1 Agroscience Research Laboratories, Crop Protection Company, Sankyo Co. Ltd. 1041 Yasu, Yasu-cho, Yasu-gun, Shiga 520-2342, Japan. tukiya@yasu.sankyo.co.jp
PMID: 12546420 DOI: 10.7164/antibiotics.55.993
Abstract

Chemical derivation methods to prepare 26-acyloxy and 26-hydroxymilbemycins, which had been reported as natural products, milbemycins alpha9, alpha10, alpha11, alpha12, alpha14, alpha15, alpha20, alpha21, alpha22, alpha23, alpha26, alpha27 from milbemycins A3, A4 were reported. Delta(2,3),delta(4,26)-milbemycins A3, A4, which had also been reported as natural products, were further prepared from milbemycins A3, A4. Their acaricidal activities were also assessed against the organophosphorus-sensitive two-spotted spider Mite (Tetranychus urticae) on primary leaves of cowpea Plants (Vigna sinesis Savi species) by spraying.

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