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  2. Indocarbazostatin and indocarbazostatin B, novel inhibitors of NGF-induced neuronal differentiation in PC12 cells. I. Screening, taxonomy, fermentation and biological activities

Indocarbazostatin and indocarbazostatin B, novel inhibitors of NGF-induced neuronal differentiation in PC12 cells. I. Screening, taxonomy, fermentation and biological activities

  • J Antibiot (Tokyo). 2002 Apr;55(4):355-62. doi: 10.7164/antibiotics.55.355.
Nobuyasu Matsuura 1 Norimasa Tamehiro Tsutomu Andoh Akira Kawashima Makoto Ubukata
Affiliations

Affiliation

  • 1 Biotechnology Research Center, Toyama Prefectural University, Kosugi, Japan.
Abstract

During the course of our screening for modulators of signal transduction of mammalian cells, we discovered two novel indolocarbazole Antibiotics, indocarbazostatin and indocabazostatin B, from a culture broth of a Streptomyces sp. as inhibitors of NGF-induced neuronal differentiation in rat pheochromocytoma PC12 cells. Indocarbazostatin and indocarbazostatin B inhibited NGF-induced neurite outgrowth from PC12 cells at 6 nM and 24 nM, respectively, whereas K-252a inhibited at 200 nM under our assay conditions.

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