2. Academic Validation
  3. Pyloricidins, novel anti-helicobacterpylori antibiotics produced by Bacillus sp. I. Taxonomy, fermentation and biological activity

Pyloricidins, novel anti-helicobacterpylori antibiotics produced by Bacillus sp. I. Taxonomy, fermentation and biological activity

  • J Antibiot (Tokyo). 2001 Nov;54(11):926-33. doi: 10.7164/antibiotics.54.926.
M Nakao 1,  K Miyagaw,  Y Nakano,  T Sakane,  M Tada,  O Nishimura,  M Fujino
Affiliations

Affiliation

  • 1 Pharmacology Research laboratories II, Pharmaceutical Research Division, Takeda Chemical Industries, Ltd., Osaka, Japan.
PMID: 11827035 DOI: 10.7164/antibiotics.54.926
Abstract

Novel anti-Helicobacter pylori Antibiotics, pyloricidins A, A1, A2, B, C and D, were discovered in the culture broth of two bacilli strains. Pyloricidins selectively inhibited the growth of H. pylori. Pyloricidin B was efficacious in the treatment of gastric Infection caused by H. pylori in Mongolian gerbils and may be promising for cure of H. pylori Infection as a single agent.

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