2. Academic Validation
  3. Antitumor agents. Part 204: synthesis and biological evaluation of substituted 2-aryl quinazolinones

Antitumor agents. Part 204: synthesis and biological evaluation of substituted 2-aryl quinazolinones

  • Bioorg Med Chem Lett. 2001 May 7;11(9):1193-6. doi: 10.1016/s0960-894x(01)00190-1.
Y Xia 1,  Z Y Yang,  M J Hour,  S C Kuo,  P Xia,  K F Bastow,  Y Nakanishi,  P Namrpoothiri,  T Hackl,  E Hamel,  H K Lee
Affiliations

Affiliation

  • 1 Natural Products Laboratory, School of Pharmacy, University of North Carolina, Chapel Hill 27599, USA.
PMID: 11354375 DOI: 10.1016/s0960-894x(01)00190-1
Abstract

A series of 2',3',4',6,7-substituted 2-aryl quinazolinones were synthesized and evaluated for biological activity. Among them, 17 displayed significant growth inhibitory action against a panel of tumor cell lines. Compound 17 was also a potent inhibitor of tubulin polymerization. Compounds 8-10 displayed selective activity against P-gp-expressing epidermoid carcinoma of the asopharynx.

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