2. Academic Validation
  3. Arylalkylidene rhodanine with bulky and hydrophobic functional group as selective HCV NS3 protease inhibitor

Arylalkylidene rhodanine with bulky and hydrophobic functional group as selective HCV NS3 protease inhibitor

  • Bioorg Med Chem Lett. 2001 Jan 22;11(2):91-4. doi: 10.1016/s0960-894x(00)00610-7.
W T Sing 1,  C L Lee,  S L Yeo,  S P Lim,  M M Sim
Affiliations

Affiliation

  • 1 Medicinal and Combinatorial Chemistry Laboratory, Institute of Molecular and Cell Biology, Singapore.
PMID: 11206478 DOI: 10.1016/s0960-894x(00)00610-7
Abstract

Arylalkylidene rhodanines 2(a-d) inhibit HCV NS3 protease at moderate concentrations. They are better inhibitors of Other serine proteases such as chymotrypsin and plasmin. However, the selectivity of arylmethyliden e rhodanines (8a, 9a) with bulkier and more hydrophobic functional groups increases by 13- and 25-fold towards HCV NS3 protease respectively.

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